468: Magnesium neuroprotection may be mediated by modulation of NMDA-R subtypes
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چکیده
منابع مشابه
The antinociceptive effect of 17β-estradiol in the nucleus paragigantocellularis lateralis of male rats may be mediated by the NMDA receptors
Introduction: The nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. The neurostreoid, 17β-estradiol found in the PGi nucleus and modulates nociception by binding to estrogen receptors and also by allosteric interaction with NMDA receptors. In this study, the role of NMDA receptors in the 17β-estradiol-induced pain modulation was investig...
متن کاملPressure-selective modulation of NMDA receptor subtypes may reflect 3D structural differences
Professional deep-water divers exposed to high pressure (HP) above 1.1 MPa suffer from High Pressure Neurological Syndrome (HPNS), which is associated with CNS hyperexcitability. We have previously reported that HP augments N-methyl-D-aspartate receptor (NMDAR) synaptic responses, increases neuronal excitability, and potentially causes irreversible neuronal damage. We now report that HP (10.1 M...
متن کاملthe antinociceptive effect of 17β-estradiol in the nucleus paragigantocellularis lateralis of male rats may be mediated by the nmda receptors
introduction: the nucleus paragigantocellularis lateralis (lpgi) is involved in the descending pain modulation. the neurostreoid, 17β-estradiol found in the pgi nucleus and modulates nociception by binding to estrogen receptors and also by allosteric interaction with nmda receptors. in this study, the role of nmda receptors in the 17β-estradiol-induced pain modulation was investigated by assess...
متن کاملNMDA receptor - mediated modulation of excitatory 1
28 29 Activity of neurons in the dorsal motor nucleus of the vagus nerve (DMV) is 30 closely regulated by synaptic input, and regulation of that input by glutamate receptors 31 on presynaptic terminals has been proposed. Presynaptic NMDA receptors have been 32 identified in a number of brain regions and act to modulate neurotransmitter release, but 33 functional presynaptic NMDA receptors have ...
متن کاملNegative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection?
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels highly permeable to calcium and essential to excitatory neurotransmission. The NMDARs have attracted much attention because of their role in synaptic plasticity and excitotoxicity. Evidence has recently accumulated that NMDARs are negatively regulated by intracellular calcium binding proteins. The calcium-dependent suppres...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2019
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2018.11.489